CovidSeniorV1, Main, Exploration, bibRecord, 000791

Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak.

Identifieur interne : 000791 ( Main/Exploration ); précédent : 000790; suivant : 000792

Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak.

Auteurs : Jose Portolés [Espagne] ; María Marques [Espagne] ; Paula L Pez-Sánchez [Espagne] ; María De Valdenebro [Espagne] ; Elena Mu Ez [Espagne] ; María Luisa Serrano [Espagne] ; Rosa Malo [Espagne] ; Estefanya García [Espagne] ; Valentín Cuervas [Espagne]

Source :

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [ 1460-2385 ] ; 2020.

RBID : pubmed:32871592

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Atteinte rénale aigüe (épidémiologie), Betacoronavirus (MeSH), Comorbidité (MeSH), Espagne (épidémiologie), Femelle (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à coronavirus (épidémiologie), Insuffisance rénale chronique (épidémiologie), Mortalité hospitalière (tendances), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (épidémiologie), Sujet âgé (MeSH), Taux de survie (tendances), Épidémies de maladies (MeSH), Études prospectives (MeSH).
MESH :
- tendances : Mortalité hospitalière, Taux de survie.
- épidémiologie : Atteinte rénale aigüe, Espagne, Infections à coronavirus, Insuffisance rénale chronique, Pneumopathie virale.
- Adulte d'âge moyen, Betacoronavirus, Comorbidité, Femelle, Hospitalisation, Humains, Mâle, Pandémies, Sujet âgé, Épidémies de maladies, Études prospectives.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Acute Kidney Injury (epidemiology), Aged (MeSH), Betacoronavirus (MeSH), Comorbidity (MeSH), Coronavirus Infections (epidemiology), Disease Outbreaks (MeSH), Female (MeSH), Hospital Mortality (trends), Hospitalization (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Prospective Studies (MeSH), Renal Insufficiency, Chronic (epidemiology), Spain (epidemiology), Survival Rate (trends).
MESH :
- geographic , epidemiology : Spain.
- epidemiology : Acute Kidney Injury, Coronavirus Infections, Pneumonia, Viral, Renal Insufficiency, Chronic.
- trends : Hospital Mortality, Survival Rate.
- Aged, Betacoronavirus, Comorbidity, Disease Outbreaks, Female, Hospitalization, Humans, Male, Middle Aged, Pandemics, Prospective Studies.

Abstract

BACKGROUND

Novel coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread, affecting >10 million cases worldwide. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and primarily manifesting as an acute respiratory failure with interstitial and alveolar pneumonia, it can also affect multiple organs. Kidney involvement was underestimated in early reports and its role remains controversial. The aim of this study was to analyse the role of kidney damage in COVID-19 outcome.

METHODS

This is a prospective cohort study of 1603 consecutive patients admitted in a University Reference Hospital in the heart of the European outbreak.

RESULTS

Median age was 64 years, 40.4% were female, 15.2% presented diabetes mellitus, 35.7% hypertension and 20.3% obesity. On admission, the prevalence of elevated serum creatinine (sCr), proteinuria, leucocyturia and haematuria were 21.0, 37.8, 31.8 and 45.6%, respectively. In total, 43.5% of those with an elevated sCr had previous chronic kidney disease (CKD) and 11.4% of those with normal sCr developed an in-hospital acute kidney injury (AKI); 17 patients needed acute haemodialysis; and 197 patients died during hospitalization. Cox proportional hazard regression confirmed that elevated baseline sCr [hazard ratio (95% confidence interval) 2.40 (1.79-3.22)], previous CKD [1.59 (1.06-2.37)], haematuria [1 + 1.68 (0.92-3.06), 2-3 + 2.69 (1.49-4.87)] and in-hospital AKI [1.50 (0.92-2.44)] were independent risk factors for in-hospital death after adjusting for age, sex and comorbidity.

CONCLUSION

The prevalence of acute and chronic kidney disease on admission and in-hospital AKI is higher than previously reported in Wuhan, and is associated with high in-hospital mortality. We should increase our awareness towards kidney involvement and design specific strategies for management of COVID-19 in these patients.

DOI: 10.1093/ndt/gfaa189
PubMed: 32871592
PubMed Central: PMC7462722

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Garcia, Estefanya" sort="Garcia, Estefanya" uniqKey="Garcia E" first="Estefanya" last="García">Estefanya García</name>
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<author><name sortKey="Cuervas, Valentin" sort="Cuervas, Valentin" uniqKey="Cuervas V" first="Valentín" last="Cuervas">Valentín Cuervas</name>
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<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospital Mortality (trends)</term>
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<term>Male (MeSH)</term>
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<term>Infections à coronavirus (épidémiologie)</term>
<term>Insuffisance rénale chronique (épidémiologie)</term>
<term>Mortalité hospitalière (tendances)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Taux de survie (tendances)</term>
<term>Épidémies de maladies (MeSH)</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Renal Insufficiency, Chronic</term>
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<term>Taux de survie</term>
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<term>Infections à coronavirus</term>
<term>Insuffisance rénale chronique</term>
<term>Pneumopathie virale</term>
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<term>Betacoronavirus</term>
<term>Comorbidity</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Prospective Studies</term>
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<term>Betacoronavirus</term>
<term>Comorbidité</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Épidémies de maladies</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Novel coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread, affecting >10 million cases worldwide. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and primarily manifesting as an acute respiratory failure with interstitial and alveolar pneumonia, it can also affect multiple organs. Kidney involvement was underestimated in early reports and its role remains controversial. The aim of this study was to analyse the role of kidney damage in COVID-19 outcome.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>This is a prospective cohort study of 1603 consecutive patients admitted in a University Reference Hospital in the heart of the European outbreak.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Median age was 64 years, 40.4% were female, 15.2% presented diabetes mellitus, 35.7% hypertension and 20.3% obesity. On admission, the prevalence of elevated serum creatinine (sCr), proteinuria, leucocyturia and haematuria were 21.0, 37.8, 31.8 and 45.6%, respectively. In total, 43.5% of those with an elevated sCr had previous chronic kidney disease (CKD) and 11.4% of those with normal sCr developed an in-hospital acute kidney injury (AKI); 17 patients needed acute haemodialysis; and 197 patients died during hospitalization. Cox proportional hazard regression confirmed that elevated baseline sCr [hazard ratio (95% confidence interval) 2.40 (1.79-3.22)], previous CKD [1.59 (1.06-2.37)], haematuria [1 + 1.68 (0.92-3.06), 2-3 + 2.69 (1.49-4.87)] and in-hospital AKI [1.50 (0.92-2.44)] were independent risk factors for in-hospital death after adjusting for age, sex and comorbidity.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The prevalence of acute and chronic kidney disease on admission and in-hospital AKI is higher than previously reported in Wuhan, and is associated with high in-hospital mortality. We should increase our awareness towards kidney involvement and design specific strategies for management of COVID-19 in these patients.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32871592</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2385</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>35</Volume>
<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>08</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</Title>
<ISOAbbreviation>Nephrol Dial Transplant</ISOAbbreviation>
</Journal>
<ArticleTitle>Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak.</ArticleTitle>
<Pagination><MedlinePgn>1353-1361</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/ndt/gfaa189</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Novel coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread, affecting >10 million cases worldwide. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and primarily manifesting as an acute respiratory failure with interstitial and alveolar pneumonia, it can also affect multiple organs. Kidney involvement was underestimated in early reports and its role remains controversial. The aim of this study was to analyse the role of kidney damage in COVID-19 outcome.</AbstractText>
<AbstractText Label="METHODS">This is a prospective cohort study of 1603 consecutive patients admitted in a University Reference Hospital in the heart of the European outbreak.</AbstractText>
<AbstractText Label="RESULTS">Median age was 64 years, 40.4% were female, 15.2% presented diabetes mellitus, 35.7% hypertension and 20.3% obesity. On admission, the prevalence of elevated serum creatinine (sCr), proteinuria, leucocyturia and haematuria were 21.0, 37.8, 31.8 and 45.6%, respectively. In total, 43.5% of those with an elevated sCr had previous chronic kidney disease (CKD) and 11.4% of those with normal sCr developed an in-hospital acute kidney injury (AKI); 17 patients needed acute haemodialysis; and 197 patients died during hospitalization. Cox proportional hazard regression confirmed that elevated baseline sCr [hazard ratio (95% confidence interval) 2.40 (1.79-3.22)], previous CKD [1.59 (1.06-2.37)], haematuria [1 + 1.68 (0.92-3.06), 2-3 + 2.69 (1.49-4.87)] and in-hospital AKI [1.50 (0.92-2.44)] were independent risk factors for in-hospital death after adjusting for age, sex and comorbidity.</AbstractText>
<AbstractText Label="CONCLUSION">The prevalence of acute and chronic kidney disease on admission and in-hospital AKI is higher than previously reported in Wuhan, and is associated with high in-hospital mortality. We should increase our awareness towards kidney involvement and design specific strategies for management of COVID-19 in these patients.</AbstractText>
<CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Portolés</LastName>
<ForeName>Jose</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Nephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Network REDInREN 016/009/009 Instituto Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marques</LastName>
<ForeName>María</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Nephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Network REDInREN 016/009/009 Instituto Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>López-Sánchez</LastName>
<ForeName>Paula</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Nephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Valdenebro</LastName>
<ForeName>María</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Nephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Network REDInREN 016/009/009 Instituto Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muñez</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Internal Medicine Department-Infectious, Diseases University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Serrano</LastName>
<ForeName>María Luisa</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Nephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Malo</LastName>
<ForeName>Rosa</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Pneumology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García</LastName>
<ForeName>Estefanya</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Nephrology Department, University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Network REDInREN 016/009/009 Instituto Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cuervas</LastName>
<ForeName>Valentín</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Internal Medicine Department-Infectious, Diseases University Hospital Puerta de Hierro, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nephrol Dial Transplant</MedlineTA>
<NlmUniqueID>8706402</NlmUniqueID>
<ISSNLinking>0931-0509</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nephrol Dial Transplant. 2020 Aug 1;35(8):1279-1281</RefSource>
<PMID Version="1">32871591</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051436" MajorTopicYN="N">Renal Insufficiency, Chronic</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">acute kidney injury</Keyword>
<Keyword MajorTopicYN="Y">chronic kidney disease</Keyword>
<Keyword MajorTopicYN="Y">outcomes</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>06</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>2</Day>
<Hour>6</Hour>
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<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Communauté de Madrid</li>
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<settlement><li>Madrid</li>
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<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Portoles, Jose" sort="Portoles, Jose" uniqKey="Portoles J" first="Jose" last="Portolés">Jose Portolés</name>
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<name sortKey="Cuervas, Valentin" sort="Cuervas, Valentin" uniqKey="Cuervas V" first="Valentín" last="Cuervas">Valentín Cuervas</name>
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<name sortKey="De Valdenebro, Maria" sort="De Valdenebro, Maria" uniqKey="De Valdenebro M" first="María" last="De Valdenebro">María De Valdenebro</name>
<name sortKey="Garcia, Estefanya" sort="Garcia, Estefanya" uniqKey="Garcia E" first="Estefanya" last="García">Estefanya García</name>
<name sortKey="Garcia, Estefanya" sort="Garcia, Estefanya" uniqKey="Garcia E" first="Estefanya" last="García">Estefanya García</name>
<name sortKey="L Pez Sanchez, Paula" sort="L Pez Sanchez, Paula" uniqKey="L Pez Sanchez P" first="Paula" last="L Pez-Sánchez">Paula L Pez-Sánchez</name>
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<name sortKey="Mu Ez, Elena" sort="Mu Ez, Elena" uniqKey="Mu Ez E" first="Elena" last="Mu Ez">Elena Mu Ez</name>
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<name sortKey="Serrano, Maria Luisa" sort="Serrano, Maria Luisa" uniqKey="Serrano M" first="María Luisa" last="Serrano">María Luisa Serrano</name>
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Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak.

Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak.

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